New York Giants vs San Francisco 49ers Odds, Picks & Prediction for Thursday Night Football

Sep 17, 2023; Inglewood, California, USA; San Francisco 49ers safety Talanoa Hufanga (29) celebrates after an interception in the second half against the Los Angeles Rams at SoFi Stadium. Mandatory Credit: Jayne Kamin-Oncea-USA TODAY SportsThe San Francisco 49ers are 10-point home favorites over the New York Giants in the NFL Week 3 TNF game on Thursday, September 21San Francisco is seeking to start the season 3-0 straight up for the ninth time in franchise history and first since 2019The Giants are 12-6 against the spread in their last 18 games but are they a good bet in our Giants vs 49ers picks for TNF?

The concern if you’re the New York Giants (1-1, 0-2 ATS) is that so far during the season, the San Francisco 49ers (2-0, 1-1 ATS) are looking like the team to beat in the NFL. The Niners are unbeaten and they haven’t even played a home game yet. They’re big favorites in the Giants vs 49ers odds here.

The Giants, meanwhile, took six quarters to just get on the scoreboard. They got shutout at home by the Dallas Cowboys and needed a huge second-half rally to beat the winless Arizona Cardinals. To top it off, they’ll be on the West Coast minus their biggest playmaker, RB Saquon Barkley.

The surprise then isn’t that the 49ers are set by oddsmakers as 10-point home favorites in the Giants vs 49ers picks. It’s that the number has shortened from an opening line of San Francisco -10.5. The 49ers are 7-0 against the spread in their last seven home games.

Let’s look deeper into the Giants vs 49ers odds and offer you our prediction for this Week 3 showdown of NFC rivals.

Giants vs 49ers Odds

In the Giants vs 49ers odds, the Niners are -575 moneyline favorites, giving them a 85.19% implied win probability. The total is set at 44.5 points.  The total has gone over in four of the last five games between these two teams.

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New York Giants vs San Francisco odds as of September 20 at DraftKings Sportsbook. Be sure to claim a DraftKings promo code to make your Giants vs 49ers picks and to bet on other Week 3 NFL action.

The Giants are 4-2 ATS in their last six visits to San Francisco. However, they are just 1-4 ATS in their last five games against the 49ers.

Kickoff for this game at Levi’s Stadium on Thursday, September 20 is set for 8:15pm ET. The broadcast is being carried by Prime Video and by DAZN in Canada.

New York Giants vs San Francisco Betting Splits

Looking at the NFL public betting splits on this game, the people are anticipating a massive performance from the 49ers. In both spread and moneyline splits in the Giants vs 49ers odds, the betting public is overwhelmingly backing San Francisco. The 49ers are drawing 91% of handle and 67% of bets as the 10-point chalk in the spread splits. San Francisco is 10-3 ATS in the last 13 games. Moneyline splits are going 97% of handle and 96% of bets to the Niners. San Fran is 14-1 SU in the last 15 games.

The over is also drawing much love from the masses in the Giants vs 49ers public betting on the total of 44.5 points. Public betting splits are showing 94% of handle and 89% of bets backing that outcome. The last four Giants vs 49ers games have all gone over.

San Francisco is the chalk in the Super Bowl odds at +650. At DraftKings, the 49ers are also given +2200 odds to go 17-0 during the regular season.

Giants vs 49ers Injury Report

Barkley (ankle) is listed as questionable, but every indication is that he won’t be playing for the next 2-3 weeks. LT Andrew Thomas (hamstring), LG Ben Bredeson (concussion), WR Wan’Dale Robinson (knee), RILB Micah McFadden (neck) and SLB Azeez Ojulari (hamstring) are also questionable for New York in the Giants vs 49ers injury report.

For the 49ers, WR Brandon Aiyuk (shoulder) is questionable. He’s caught 11 passes in two games for a 15.6-yard average and two TDs.

Life Without Saquon Deadly for Giants

Last season as the Giants made the NFL playoffs, Barkley had 352 touches. That was the third-most of any NFL player. Through two games this season, he was on pace for 323 touches. It’s not a stretch to say the offense runs through him.

Saquon Barkley is listed as questionable for Thursday's game against the 49ers 😬 pic.twitter.com/Ryr9mwnHt9

— NFL on ESPN (@ESPNNFL) September 20, 2023

With double threat Barkley in his backfield, Giants QB Daniel Jones has thrown for 46 TDs against 20 interceptions. Minus Barkley, that ratio drops to 16:17. Jones shows a passer rating of 100.1 on play action calls. It slips to 56.8 on straight drop backs.

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Everything Clicking for San Francisco

In their season opener at Pittsburgh, the 49ers steamrolled the Steelers 30-7. Last week on the road to face the Rams, even without the team bringing their A game, the Niners found a way to outlast a game squad from LA.

There are historic numbers at work for San Francisco right now. It’s the ninth time the team has opened a season 2-0. In six of the previous eight occasions, the 49ers made the playoffs. The last time it happened in 2019, they went to the Super Bowl.

49ers have scored at least 30 points in 8 of 11 games since Brock Purdy has taken over at QB. pic.twitter.com/z6whae8Y4Q

— John Chapman (@JL_Chapman) September 17, 2023

They’ve also scored 30 or more points in eight of the 11 games since Brock Purdy took over as San Francisco’s QB1. Purdy looks like an attractive option to include in any Giants vs 49ers same game parlays this week.

Giants vs 49ers Prediction

Facing a short week, the Giants were opting to stay in Arizona and practice in preparation for this game. However, nothing can prepare them for facing this San Francisco juggernaut minus Barkley. New York has been outscored 46-0 in the first half this season. Do that against the 49ers and it’s going to get ugly fast.

Then you factor in the potential to be missing 40% of his offensive line against what was the NFL’s best defense last season, and it ps to be a long night for Giants QB Jones.

Giants vs 49ers Picks: San Francisco 49ers -10 (-110)

TNF Record: 2-0-0

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